Technical Team

Mélanie GUILLEMIN obtained her professional Bachelor’s degree from the University of Burgundy in 2014.

During her professional Bachelor’s degree, she completed a 6-month internship at IMATHERA, which led her to join the IMAPPI project (ANR-10-EQPX-05-01) for one year.She then became a permanent member of the IMATHERA team, contributing to different research areas such as cardiology, oncology, and pulmonary fibrosis, ranging from in vitro experiments to in vivo studies.

She is actively involved in the execution of both service and R&D studies within the platform.Her training and experience have allowed her to develop strong skills in animal experimentation, including treatment administration, organ collection, and surgical procedures, as well as in vitro techniques such as cell culture and flow cytometry.

Romain RUFFIN obtained his higher national diploma (BTS) in Biotechnology in 2019.
Following this diploma, he worked for 5 years at Oncodesign Services. This experience allowed him to
acquire skills in animal experimentation such as administering treatments, harvesting organs using
various methods, and performing surgery.
In addition, he was also trained in in vitro skills, such as culturing various tumor cell lines, performing
flow cytometry, PCR.
Since 2024, he has joined the IMATHERA team as a research technician within the COMETE project.

Celia Teixeira Alves obtained a Master’s degree in Molecular Oncology and Biotherapies from the Faculty of Science and Technology of Limoges in 2024. During her Master’s training, she completed two research internships at the Laboratory of Agroresources, Biomolecules and Chemistry for Innovation in Health (LABCiS) in Limoges. Her first project focused on investigating the effects of novel pharmacomodulated chalcones on apoptosis induction in prostate cancer cells, allowing her to develop strong skills in cell culture, cytotoxicity assays (MTT), ELISA, and Western blotting techniques. Her second internship focused on COX-2-targeting photosensitizers for photodynamic therapy in colorectal cancer. Through this project, she developed solid expertise in flow cytometry and photodynamic therapy, while also gaining experience in confocal microscopy, PCR techniques, immunofluorescence, and image analysis (ImageJ).

In 2025, she joined the Paris Cardiovascular Research Center (PARCC, Team 6 : Integrative physiopathology and therapy of cardiac diseases ) as an Assistant Engineer in molecular and cellular biology and animal experimentation. Her research focused on evaluating novel antibodies targeting molecular pathways involved in post-myocardial infarction fibrosis using both in vitro and in vivo approaches. Her work included human and murine cell culture, transfection, luciferase reporter assays, Western blotting, ELISA, mouse line management, genotyping, injections, dissections, and histological analyses.

Since 2026, she has been working within the IMATHERA team as an In Vivo Study Engineer as part of the i-nano-T project. Her work focuses on conducting preclinical studies to evaluate the oncotheranostic potential of selected nanoparticles, primarily through in vivo approaches along with in vitro experiments. Her responsibilities include conducting in vivo studies and cellular assays, acquiring and processing imaging data, analyzing experimental results, and contributing to project monitoring and scientific reporting. She is also involved in laboratory animal workflow management, daily animal care, preparation and implementation of experimental procedures, as well as the maintenance of laboratory equipment and facilities.